Question:

Could you elucidate the mechanism by which Agena Bioscience conducts its genetic testing procedures?

Answer:

1.

Sample Preparation

: Biological samples containing DNA are collected and prepared for analysis. This involves isolating the DNA and possibly amplifying it to ensure there is enough material for testing.

2.

DNA Analysis

: The MassARRAY® System uses a process called matrix-assisted laser desorption/ionization (MALDI) to ionize the DNA fragments. Then, time-of-flight (TOF) mass spectrometry measures the mass-to-charge ratio of these ions to generate a unique spectral fingerprint for each fragment.

3.

Data Interpretation

: The resulting data is then interpreted to identify specific genetic markers. This could include single nucleotide polymorphisms (SNPs), insertions and deletions (INDELs), and other genetic variations.

4.

Reporting

: The identified genetic markers are reported in the context of the individual’s health, potential disease risks, or other relevant genetic information.

The MassARRAY® System is noted for its reliability and specificity, even when working with trace amounts of genetic target material. It’s also versatile, supporting a broad range of applications from pharmacogenetics to tumor profiling and liquid biopsy.

Agena Bioscience’s technology thus provides a robust and scalable solution for genetic testing, enabling laboratories to conduct detailed genetic analysis efficiently and cost-effectively.